a biotech company in the US
successfully completed route optimization and scale up synthesis of a peptide product with 87 synthetic steps
Complex structure: 87 steps, and the total yield is 0.08%
Large quantity with high purity standard: 2X100 g, >95% purity with no single impurity >1%,
Tight timeline:<6 months
Optimized synthetic routes by running small scale tests in parallel in 1.5 months
Scaled up the process within 4.5 months
Analytical team developed new purification methods at the same time
Sufficient resource ensured streamlined process
Delivered: 2X100 g, no single impurity>1% within 6 months
The customer received the IND approval within 4 months afterwards