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Case Study

Peptide Discovery

Peptide CMC

Peptide Conjugation

Amino Acid

Case Study

Peptide Discovery

Peptide Discovery

Peptide CMC

Peptide Conjugation

Client:

a biotech company in the US


Project:

successfully completed route optimization and scale up synthesis of a peptide product with 87 synthetic steps


Challenges:

Complex structure: 87 steps, and the total yield is 0.08%

Large quantity with high purity standard: 2X100 g, >95% purity with no single impurity >1%,

Tight timeline:<6 months


Solution:

Optimized synthetic routes by running small scale tests in parallel in 1.5 months

Scaled up the process within 4.5 months

Analytical team developed new purification methods at the same time

Sufficient resource ensured streamlined process

 

Results:

Delivered: 2X100 g, no single impurity>1% within 6 months

The customer received the IND approval within 4 months afterwards



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