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Peptide synthesis_Custom Peptide Synthesis Peptide synthesis_Custom Peptide Synthesis

Custom Peptide Synthesis

Accelerate peptide synthesis with our strong chemistry capability

Services & Solutions

Services & Solutions





Peptide Discovery

Peptide Discovery

Peptide CMC

Peptide Conjugation

Amino Acid

Case Study

Custom Peptide Synthesis

Custom Peptide Synthesis

Collaboration Model


In 2022, WuXi TIDES peptide platform has provided custom peptide services for 300+ customers globally and delivered 20,000+ peptides from mg to kg scale. We offer numerous options for discovery scales, purity levels, modifications, and salt forms. Our aim is to provide peptide products for your drug discovery research quickly with high quality!

Have peptide projects on your hand? Leave your contact information and we'll approach you within 2 working days!

Discovery Peptide Synthesis Service Highlights

Peptide Synthesis with Large Diversity: A wide choice for peptide synthesis including linear peptide(single SPPS length up to 70 AAs, ligation length up to 200 AAs), macrocyclic peptide, modified peptide and peptide based complex conjugates.

Excellent Quality & Quantity: We will provide the peptides to meet your requirements with purity ranging from crude to 99.9% & scale from mg to kg.

High Success Rate: Our professional technical team can ensure you more than 98% success rate1 in peptide synthesis.

Quick Turnaround Time: Peptide synthesis with short timeline as fast as 3 days2 to ensures your downstream research in a timely manner.

High-Throughput Peptide Synthesis: We have rich experience in synthesizing custom peptide libraries for peptide structure-activity-relationship (SAR) study.

Comprehensive Analysis Support: We provide default purity/MS profile and additional service including amino acid analysis, endotoxin, etc. after the completion of peptide synthesis.

   1. All peptides in the 2022 projects with regular requests were successfully synthesized with desired quality.
   2. Turnaround time includes all business days from order confirmation to the completion of synthesis, not including shipping time. Turnaround time may be expected longer for the orders of over 60 peptides, or with rare modifications, salt exchange.

Peptide manufacturing_linear peptide

Linear Peptide Synthesis:


Fmoc solid-phase peptide synthesis (SPPS)

Fragment Coupling



2-10 AA, single SPPS, 5-7 days

11-20 AA , single SPPS, 8-10 days

21-30 AA , single SPPS, 11-13 days

31-40 AA , single SPPS, 14-16 days

40-60 AA, single SPPS, 17-30 days

60-130 AA, conjugation/ligation, case by case

Peptide synthesis_cyclic peptide

Cyclic Peptide Synthesis

Cyclization is now a common strategy for improving pharmacological properties of a peptide from its linear precursor, including affinity and specificity, proteolytic stability, and/or solubility.

Our team has rich experience in cyclic peptide synthesis, with 100,000+ cyclic peptides successfully delivered.

Cyclization strategies include single/double/triple disulfide, click cyclization, lactone, lactam, RCM, etc. The cyclization positions can include head-to-tail, head-to-sidechain, sidechain-to-sidechain, sidechain-to-tail.

Custom peptide synthesis_Head to tail

Head to tail

Peptide manufacturing_Head to sidechain

Head to sidechain

Peptide synthesis_Sidechain to sidechain

Sidechain to sidechain

Custom peptide synthesis_Sidechain to tail

Sidechain to tail

Experience in :

Disulfide peptide (single/double/ triple disulfide);

Click peptide

Thioether cyclization

RCM cyclization

Lactam cyclization

Bicyclic peptides

Lactone cyclization

Peptide manufacturing_Bicyclo-disulfide bridge

Bicyclo-disulfide bridge

(Three pairs of S-S bond formation achieved as well)
Peptide synthesis_RCM monocyclic peptide

RCM monocyclic peptide

Custom peptide synthesis_Bicyclic peptide

Bicyclic peptide

Peptide synthesis company_Click peptide

Click peptide

Peptide synthesis_Thioether cyclization

Thioether cyclization

Modified Peptide Synthesis

We offer a comprehensive range of special modifications to meet your needs. A few examples are shown below, including N-terminal modification, C-terminal modification, dye/fluorescent labeling, biotin-labeling, PEGylation, post-translational modification, DOTA/NOTA labeling, and isotope labeling.

Apart from sidechain and backbone modification, we can also incorporate unnatural amino acids into the sequences. For unnatural amino acid catalog products, please visit here for details.

Modified Peptide Synthesis

N-terminal modification

C-terminal modification

Dye and Fluorescent (site specific modification)

PTMs (site specific modification)

Isotope labeling


H (free amine)







Lipid tail

Dye and Fluorescent labeling

-OH (free)

Ester (-Ome)



Active ester (NHS; TFP; PFP)

Dye and Fluorescent (by conjugation)



5-FAM (5,6-FAM);





Acetylation (Lys)

Methylation (Arg)

Phosphorylation (Ser, Thr, Tyr)





1H – D

12C – 13C

14N – 15N

13C, 15N – Lys

13C, 15N – Arg

13C, 15N – Ala

13C, 15N – Ile

13C, 15N – Leu

13C, 15N – Pro

13C, 15N – Phe

13C, 15N – Val

N-linked glycopeptide synthesis

O-linked glycopeptide synthesis

C-linked glycopeptide synthesis

S-linked glycopeptide synthesis

Automatic Peptide Synthesizer

For routine peptide synthesis, automatic synthesizers can accelerate SPPS portion.  Our synthesizers include CSBio, CEM Liberty Blue, and Biotage Syro II. With these advanced synthesizers, as well as a variety of prep-HPLC equipment installed in house, your requested compound can be ready within as fast as 5 days. 

Peptide synthesis company_CEM Liberty Blue

CEM Liberty Blue

As fast as 5 min/position

Microwave synthesizer


Sequential synthesis

0.1-0.2 mmol

Custom peptide synthesis_Biotage Syro II

Biotage Syro II

High throughput synthesizer

24/48/96 channel

Parallel synthesis

Suitable for SAR screening

25 umol

Peptide manufacturing_CSBio Synthesizer

CSBio Synthesizer


Parallel synthesis

0.2-0.5 mmol

Peptide synthesis_Symphony X

Symphony X

High throughput synthesizer

24 channel

Parallel synthesis

0.1-0.2 mmol