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Peptide Discovery
Peptide Discovery
Peptide CMC
Peptide Conjugation
Amino Acid
Case Study
Custom Peptide Synthesis
Custom Peptide Synthesis
Collaboration Model
Quotation
Since 2012, WuXi STA peptide platform has provided custom peptide services for 1,000+ customers globally. We offer numerous options for discovery scales, purity levels, modifications, and salt forms. Our aim is to provide peptide products for your drug discovery research quickly with high quality!
Have peptide projects on your hand? Leave your contact information and we'll approach you within 2 working days!
Over 98% success rate
Broad synthetic scale from milligram to kilogram
Variety of peptide products, including linear peptide, macrocyclic peptide, modified peptide and peptide based complex conjugates
Products can be delivered as on-resin, crude, as well as purified powder at desired purity up to 99%
Each peptide comes with MS and HPLC/UPLC analytics data
Quick turnaround time - most peptides under 40AA are completed within 2 weeks
Fmoc solid-phase peptide synthesis (SPPS)
Fragment Coupling
Ligation
2-10 AA, single SPPS, 5-7 days
11-20 AA , single SPPS, 8-10 days
21-30 AA , single SPPS, 11-13 days
31-40 AA , single SPPS, 14-16 days
40-60 AA, single SPPS, 17-30 days
60-130 AA, conjugation/ligation, case by case
Cyclization is now a common strategy for improving pharmacological properties of a peptide from its linear precursor, including affinity and specificity, proteolytic stability, and/or solubility.
Our team has rich experience in cyclic peptide synthesis, with 80,000+ cyclic peptides successfully delivered.
Cyclization strategies include single/double/triple disulfide, click cyclization, lactone, lactam, RCM, etc. The cyclization positions can include head-to-tail, head-to-sidechain, sidechain-to-sidechain, sidechain-to-tail.
Head to tail
Head to sidechain
Sidechain to sidechain
Sidechain to tail
Disulfide peptide (single/double/ triple disulfide);
Click peptide
Thioether cyclization
RCM cyclization
Lactam cyclization
Bicyclic peptides
Bicyclo-disulfide bridge
(Three pairs of S-S bond formation achieved as well)
RCM monocyclic peptide
Bicyclic peptide
Click peptide
Cyclosporine analog
Thioether cyclization
We offer a comprehensive range of special modifications to meet your needs. A few examples are shown below, including N-terminal modification, C-terminal modification, dye/fluorescent labeling, biotin-labeling, PEGylation, post-translational modification, DOTA/NOTA labeling, and isotope labeling.
Apart from sidechain and backbone modification, we can also incorporate unnatural amino acids into the sequences. For unnatural amino acid catalog products, please visit here for details.
Modified Peptide
N-terminal modification
C-terminal modification
Dye and Fluorescent (site specific modification)
PTMs (site specific modification)
Isotope labeling
Glycopeptide
H (free amine)
Acetylation
Fmoc
CBZ
Bz
Pyr
Biotinylation
Lipid tail
Dye and Fluorescent labeling
-OH (free)
Ester (-Ome)
-NH2
-NH-Me
Active ester (NHS; TFP; PFP)
Dye and Fluorescent (by conjugation)
Biotin；
FITC；
5-FAM (5,6-FAM)；
Dansyl-
TAMTA-
MCA-
Rhodamine
Acetylation (Lys)
Methylation (Arg)
Phosphorylation (Ser, Thr, Tyr)
Lipidation
Glycosylation
SUMOylation
Ubiquitionation
1H – D
12C – 13C
14N – 15N
13C, 15N – Lys
13C, 15N – Arg
13C, 15N – Ala
13C, 15N – Ile
13C, 15N – Leu
13C, 15N – Pro
13C, 15N – Phe
13C, 15N – Val
N-linked glycopeptide synthesis
O-linked glycopeptide synthesis
C-linked glycopeptide synthesis
S-linked glycopeptide synthesis
For routine peptide synthesis, we apply automatic synthesizers to accelerate SPPS portion. Our synthesizers include CEM Liberty Blue (accelerated coupling enables one 20-AA sequence could be complete within 2 hours), Biotage Syro II (parallel synthesis for up to 96 sequences, perfect for initial SAR screening), CSBio (parallel synthesis for up to 3 sequences at 50-500 mg), and Symphony X (parallel synthesis for up to 24 sequences at 5-10 mg). With these advanced synthesizers, as well as a variety of prep-HPLC equipment installed in house, your requested compound can be ready within as fast as 5 days.
As fast as 5 min/position
Microwave synthesizer
12-channel
Sequential synthesis
0.1-0.2 mmol
High throughput synthesizer
24/48/96 channel
Parallel synthesis
Suitable for SAR screening
25 umol
3-channel
Parallel synthesis
0.2-0.5 mmol
High throughput synthesizer
24 channel
Parallel synthesis
0.1-0.2 mmol
