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Peptide Discovery
Peptide Discovery
Peptide CMC
Peptide Conjugation
Amino Acid
Case Study
Custom Peptide Synthesis
Custom Peptide Synthesis
Collaboration Model
Quotation
In 2022, WuXi TIDES peptide platform has provided custom peptide services for 300+ customers globally and delivered 20,000+ peptides from mg to kg scale. We offer numerous options for discovery scales, purity levels, modifications, and salt forms. Our aim is to provide peptide products for your drug discovery research quickly with high quality!
Have peptide projects on your hand? Leave your contact information and we'll approach you within 2 working days!
Peptide Synthesis with Large Diversity: A wide choice for peptide synthesis including linear peptide(single SPPS length up to 70 AAs, ligation length up to 200 AAs), macrocyclic peptide, modified peptide and peptide based complex conjugates.
Excellent Quality & Quantity: We will provide the peptides to meet your requirements with purity ranging from crude to 99.9% & scale from mg to kg.
High Success Rate: Our professional technical team can ensure you more than 98% success rate1 in peptide synthesis.
Quick Turnaround Time: Peptide synthesis with short timeline as fast as 3 days2 to ensures your downstream research in a timely manner.
High-Throughput Peptide Synthesis: We have rich experience in synthesizing custom peptide libraries for peptide structure-activity-relationship (SAR) study.
Comprehensive Analysis Support: We provide default purity/MS profile and additional service including amino acid analysis, endotoxin, etc. after the completion of peptide synthesis.
Note:
1. All peptides in the 2022 projects with regular requests were successfully synthesized with desired quality.
2. Turnaround time includes all business days from order confirmation to the completion of synthesis, not including shipping time. Turnaround time may be expected longer for the orders of over 60 peptides, or with rare modifications, salt exchange.
Fmoc solid-phase peptide synthesis (SPPS)
Fragment Coupling
Ligation
2-10 AA, single SPPS, 5-7 days
11-20 AA , single SPPS, 8-10 days
21-30 AA , single SPPS, 11-13 days
31-40 AA , single SPPS, 14-16 days
40-60 AA, single SPPS, 17-30 days
60-130 AA, conjugation/ligation, case by case
Cyclization is now a common strategy for improving pharmacological properties of a peptide from its linear precursor, including affinity and specificity, proteolytic stability, and/or solubility.
Our team has rich experience in cyclic peptide synthesis, with 100,000+ cyclic peptides successfully delivered.
Cyclization strategies include single/double/triple disulfide, click cyclization, lactone, lactam, RCM, etc. The cyclization positions can include head-to-tail, head-to-sidechain, sidechain-to-sidechain, sidechain-to-tail.
Head to tail
Head to sidechain
Sidechain to sidechain
Sidechain to tail
Disulfide peptide (single/double/ triple disulfide);
Click peptide
Thioether cyclization
RCM cyclization
Lactam cyclization
Bicyclic peptides
Lactone cyclization
Bicyclo-disulfide bridge
(Three pairs of S-S bond formation achieved as well)
RCM monocyclic peptide
Bicyclic peptide
Click peptide
Cyclosporine analog
Thioether cyclization
We offer a comprehensive range of special modifications to meet your needs. A few examples are shown below, including N-terminal modification, C-terminal modification, dye/fluorescent labeling, biotin-labeling, PEGylation, post-translational modification, DOTA/NOTA labeling, and isotope labeling.
Apart from sidechain and backbone modification, we can also incorporate unnatural amino acids into the sequences. For unnatural amino acid catalog products, please visit here for details.
Modified Peptide Synthesis
N-terminal modification
C-terminal modification
Dye and Fluorescent (site specific modification)
PTMs (site specific modification)
Isotope labeling
Glycopeptide
H (free amine)
Acetylation
Fmoc
CBZ
Bz
Pyr
Biotinylation
Lipid tail
Dye and Fluorescent labeling
-OH (free)
Ester (-Ome)
-NH2
-NH-Me
Active ester (NHS; TFP; PFP)
Dye and Fluorescent (by conjugation)
Biotin；
FITC；
5-FAM (5,6-FAM)；
Dansyl-
TAMTA-
MCA-
Rhodamine
Acetylation (Lys)
Methylation (Arg)
Phosphorylation (Ser, Thr, Tyr)
Lipidation
Glycosylation
SUMOylation
Ubiquitionation
1H – D
12C – 13C
14N – 15N
13C, 15N – Lys
13C, 15N – Arg
13C, 15N – Ala
13C, 15N – Ile
13C, 15N – Leu
13C, 15N – Pro
13C, 15N – Phe
13C, 15N – Val
N-linked glycopeptide synthesis
O-linked glycopeptide synthesis
C-linked glycopeptide synthesis
S-linked glycopeptide synthesis
For routine peptide synthesis, automatic synthesizers can accelerate SPPS portion. Our synthesizers include CSBio, CEM Liberty Blue, and Biotage Syro II. With these advanced synthesizers, as well as a variety of prep-HPLC equipment installed in house, your requested compound can be ready within as fast as 5 days.
As fast as 5 min/position
Microwave synthesizer
12-channel
Sequential synthesis
0.1-0.2 mmol
High throughput synthesizer
24/48/96 channel
Parallel synthesis
Suitable for SAR screening
25 umol
3-channel
Parallel synthesis
0.2-0.5 mmol
High throughput synthesizer
24 channel
Parallel synthesis
0.1-0.2 mmol
