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Custom Peptide Synthesis

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Peptide Discovery

Peptide Discovery

Peptide CMC

Peptide Conjugation

Amino Acid

Case Study

Custom Peptide Synthesis

Custom Peptide Synthesis

Collaboration Model

Quotation

Since 2012, WuXi STA peptide platform has provided custom peptide services for 1,000+ customers globally. We offer numerous options for discovery scales, purity levels, modifications, and salt forms. Our aim is to provide peptide products for your drug discovery research quickly with high quality!


Have peptide projects on your hand? Leave your contact information and we'll approach you within 2 working days!

Discovery Peptide Synthesis Service Highlights

Over 98% success rate

Broad synthetic scale from milligram to kilogram

Variety of peptide products, including linear peptide, macrocyclic peptide, modified peptide and peptide based complex conjugates

Products can be delivered as on-resin, crude, as well as purified powder at desired purity up to 99%

Each peptide comes with MS and HPLC/UPLC analytics data

Quick turnaround time - most peptides under 30AA are completed within 2 weeks

linear peptide

Linear Peptide:

Approach:

Fmoc solid-phase peptide synthesis (SPPS)

Fragment Coupling

Ligation

Speed:

2-10 AA, single SPPS, 5-7 days

11-20 AA , single SPPS, 8-10 days

21-30 AA , single SPPS, 11-13 days

31-40 AA , single SPPS, 14-16 days

40-60 AA, single SPPS, 17-30 days

60-130 AA, conjugation/ligation, case by case

cyclic peptide

Cyclic Peptide

Cyclization is now a common strategy for improving pharmacological properties of a peptide from its linear precursor, including affinity and specificity, proteolytic stability, and/or solubility.

Our team has rich experience in cyclic peptide synthesis, with 80,000+ cyclic peptides successfully delivered.

Cyclization strategies include single/double/triple disulfide, click cyclization, lactone, lactam, RCM, etc. The cyclization positions can include head-to-tail, head-to-sidechain, sidechain-to-sidechain, sidechain-to-tail.

Head to tail

Head to tail

Head to sidechain

Head to sidechain

Sidechain to sidechain

Sidechain to sidechain

Sidechain to tail

Sidechain to tail

Experience in :

Disulfide peptide (single/double/ triple disulfide);

Click peptide

Thioether cyclization

RCM cyclization

Lactam cyclization

Bicyclic peptides

Lactone cyclization

Bicyclo-disulfide bridge

Bicyclo-disulfide bridge

(Three pairs of S-S bond formation achieved as well)
RCM monocyclic peptide

RCM monocyclic peptide

Bicyclic peptide

Bicyclic peptide

Click peptide

Click peptide

Cyclosporine analog

Cyclosporine analog

Thioether cyclization

Thioether cyclization

Modified Peptide

We offer a comprehensive range of special modifications to meet your needs. A few examples are shown below, including N-terminal modification, C-terminal modification, dye/fluorescent labeling, biotin-labeling, PEGylation, post-translational modification, DOTA/NOTA labeling, and isotope labeling.

Apart from sidechain and backbone modification, we can also incorporate unnatural amino acids into the sequences. For unnatural amino acid catalog products, please visit here for details.

Modified Peptide

N-terminal modification

C-terminal modification

Dye and Fluorescent (site specific modification)

PTMs (site specific modification)

Isotope labeling

Glycopeptide

H (free amine)

Acetylation

Fmoc

CBZ

Bz

Pyr

Biotinylation

Lipid tail

Dye and Fluorescent labeling

-OH (free)

Ester (-Ome)

-NH2

-NH-Me

Active ester (NHS; TFP; PFP)

Dye and Fluorescent (by conjugation)

Biotin;

FITC;

5-FAM (5,6-FAM);

Dansyl-

TAMTA-

MCA-

Rhodamine

Acetylation (Lys)

Methylation (Arg)

Phosphorylation (Ser, Thr, Tyr)

Lipidation

Glycosylation

SUMOylation

Ubiquitionation

1H – D

12C – 13C

14N – 15N

13C, 15N – Lys

13C, 15N – Arg

13C, 15N – Ala

13C, 15N – Ile

13C, 15N – Leu

13C, 15N – Pro

13C, 15N – Phe

13C, 15N – Val

N-linked glycopeptide synthesis

O-linked glycopeptide synthesis

C-linked glycopeptide synthesis

S-linked glycopeptide synthesis

Automatic and High Throughput Peptide Synthesizer

For routine peptide synthesis, we apply automatic synthesizers to accelerate SPPS portion.  Our synthesizers include CEM Liberty Blue (accelerated coupling enables one 20-AA sequence could be complete within 2 hours), Biotage Syro II (parallel synthesis for up to 96 sequences, perfect for initial SAR screening), CSBio (parallel synthesis for up to 3 sequences at 50-500 mg), and Symphony X (parallel synthesis for up to 24 sequences at 5-10 mg). With these advanced synthesizers, as well as a variety of prep-HPLC equipment installed in house, your requested compound can be ready within as fast as 5 days.

CEM Liberty Blue

CEM Liberty Blue

As fast as 5 min/position

Microwave synthesizer

12-channel

Sequential synthesis

0.1-0.2 mmol

Biotage Syro II

Biotage Syro II

High throughput synthesizer

24/48/96 channel

Parallel synthesis

Suitable for SAR screening

25 umol

CSBio Synthesizer

CSBio Synthesizer

3-channel

Parallel synthesis

0.2-0.5 mmol

Symphony X

Symphony X

High throughput synthesizer

24 channel

Parallel synthesis

0.1-0.2 mmol